Cadiar-DX

Cadiar-DX^® Tablet: Each film-coated tablet contains Calcium Carbonate USP 1500 mg equivalent to 600 mg of elemental Calcium and Cholecalciferol (Vitamin D3) USP 400 IU.

• Treatment of osteoporosis, rickets, osteomalacia, tetany & hypoparathyroidism.

• As supplement during pregnancy & lactation.

• In kidney disease and pancreatitis.

• During therapy with antiseizure medications.

• The prevention and treatment of calcium deficiency/vitamin-D3 deficiency especially in the housebound and institutionalized elderly subjects.

Adults and elderly and children 12 years of age & above: 2 tablets per day, preferably one tablet each morning and evening with a full glass of water.

Children: Not recommended for children under 12 years.

The use of calcium supplements has rarely given rise to mild gastro-intestinal disturbances such as constipation, flatulence, nausea, gastric pain, diarrhea. Following administration of vitamin-D3 supplements occasional skin rash has been reported. Hypercalciuria and in rare cases hypercalcemia have been seen with long term treatment at high dosages.

Patients with mild to moderate renal failure or mild hypercalciuria should be supervised carefully. In patients with a history of renal stones urinary calcium excretion should be measured to exclude hypercalciuria. With long term treatment it is advisable to monitor serum and urinary calcium levels and kidney function and reduce and stop treatment temporarily if urinary calcium exceeds 7.5 mmol/24 hours. Allowances should be made for Calcium and Vitamin-D3 supplements from other sources.

The risk of hypocalcaemia should be considered in patients taking thiazide diuretics. Concomitant treatment with Phenytoin or Barbiturates can decrease the effect of Vitamin-D3 because of metabolic activation. Concomitant use of glucocorticoids can decrease the effect of Vitamin D3. The effects of digitalis and other Cardiac Glycosides may be accentuated with the oral administration of Calcium combined with Vitamin D3. Calcium salts may reduce the absorption of Thyroxin, Sodium fluoride, Quinolone or Tetracycline antibiotics or Iron. It is advisable to allow a minimum period of four hours before taking the Calcium products.

The most serious consequences of acute or chronic overdose are hypercalcaemia due to Vitamin-D3 toxicity. Symptoms include nausea, vomiting, polyuria and constipation. Chronic overdose can lead to vascular and organic calcification as a result of hypocalcaemia. Treatment should consist of stopping all intakes of calcium and Vitamin-D3 and rehydration.

Store at temperature not exceeding 30º C in a dry place. Protect from light and moisture.

Cadiar-DX^® Tablet: Each box contains 3x10’s tablets in Alu-PVDC blister strips.